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Pure Motivation » General Discussion » Health and Wellness/ الصحة و اللياقة » Health Benefits of Broccolli

Health Benefits of Broccolli

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1 Health Benefits of Broccolli on Sat Sep 08, 2012 8:08 am


Senior Member
Senior Member


Broccoli for cancer.

50% of cancers in the world today;
are caused by failures in the regulation of the cell cycle, a cycle
that starts with the formation of cells and ends with its apoptosis or
programmed cell death. The regulation of this cell cycle is achieved by a
protein called p53 (name assigned by its molecular mass). The protein
p53 is a natural tumor suppressor and it is in charge of ordering the
human cells when they came to an end of life and it's time to die,
process known as apoptosis.

For many factors, mainly DNA damage, some times the protein p53 fails,
and the tumor cells that were suppose to die in this natural cell cycle
known as apoptosis, continue growing, some times in the form of tumors
and some times as its malignant form, cancer. But it seems scientists
have now found an active constituent in Broccoli that may help in this
fight against cancer, let's have a look.


Family: Brassicaceae
Genus: Brassica
Common name: Broccoli


Scientist and doctors have investigated different means to achieve what
protein p53 achieves on a natural form, cell cycle regulation and
natural death of tumor cells, stopping the spread of the tumors and
their malignant forms cancer. In their search for chemicals and
molecules that may achieve this function scientist have also looked into
natural products and traditional herbal remedies as source of active
constituents that may exert this anticancer properties. Recently their
interest focused in a cruciferous plant, Broccoli, and one of its active
constituents, diindolylmethane, a compound that is produced naturally
during the digestion of indole-3-carbinol, a molecule found in Broccoli
and other cruciferous vegetables of its family, the Brassicaceae or

Broccoli, is rich in vitamin C (in 100 grams we have our daily
recommended intake of vitamin C) and fiber. It has recently been more
and more in the scope of scientists as some of the active constituents
found on it have demonstrated incredible health benefits, among some of
them certain active constituents as diindolylmethane, have exerted
certain anticancer properties in cancer /breast cancer studies.


But which active constituent found in Broccoli is responsible for this anticancer properties?

The 3,3'-Diindolylmethane or DIM, a cancer preventive phytochemical from
Brassica vegetables found in broccoli, but also in Brussels sprouts,
cabbage and kale is the active constituent that so far has been proven
in several studies and clinical trials [1,2,3,4] to exert anticancer,
cancer preventive and inhibiting properties in at least breast cancer
and prostate cancer.

3,3'-Diindolylmethane (DIM), inhibited breast cancer cell growth and
proliferation in vitro and in vivo, being also able to induce arrest in
human prostate cancer cell lines HCT-116 and Colo-320 [1,4].

Another naturally occurring active constituent of broccoli,
sulforaphane, has been extensively studied for cancer prevention due to
ist chemopreventive properties[6].


Many are the active constituents found in Broccoli but among all of them
we would like to highlight one, Kaempferol, and active constituent
known for its health benefits and wonderful properties.

Kaempferol is a type of flavonoid, a flavonol, found on natural sources
as apples, broccoli, Witch hazel, tea, kenaf, cabbage, kale, beans,
endive, leek, tomato, strawberries and grapes, as well as in herbs and
plants frequently used in herbal remedies and traditional medicine (e.g.
Ginkgo biloba, Tilia spp, Equisetum spp, Moringa oleifera, Sophora
japonica and propolis). It has been scientifically proven that the
consumption of foods rich in kaempferol may reduce the risk of
developing health problems such as cancer and cardiovascular disease.

Among the properties of Kaempferol we can mention its anti-inflammatory,
antimicrobial, anti-oxidant, anti-cancer, cardioprotective,
neuroprotective, anti-diabetic, anti-osteoporotic,
estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic
activities [5].


[1] 3,3'-Diindolylmethane inhibits breast cancer cell growth via
miR-21-mediated Cdc25A degradation. Jin Y. Laboratory of Cell Cycle and
Cancer, College of Life Sciences, Capital Normal University, HaiDian
District, Beijing 100048, China.

[2] The Indolic Diet-Derivative, 3,3'-Diindolylmethane, Induced
Apoptosis in Human Colon Cancer Cells through Upregulation of NDRG1.
Lerner A, Grafi-Cohen M, Napso T, Azzam N, Fares F.
Pediatric Gastroenterology and Nutrition Unit, Carmel Medical Center, Haifa 34362, Israel.

[3] Inhibition of fatty acid synthase and Sp1 expression by 3,3'-diindolylmethane in human breast cancer cells.
Saati GE, Archer MC.
Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

[4] 3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status.
Vivar OI, Lin CL, Firestone GL, Bjeldanes LF.
Department of Nutritional Sciences and Toxicology, 119 Morgan Hall, University of California, Berkeley, CA 94720, USA.

[5] A Review on the Dietary Flavonoid Kaempferol.
Calderón-Montaño JM, Burgos-Morón E, Pérez-Guerrero C, López-Lázaro M.
Department of Pharmacology, Faculty of Pharmacy. University of Seville, C/ Profesor García González, no 2, 41012, Sevilla, Spain

[6] Organ-specific exposure and response to sulforaphane, a key
chemopreventive ingredient in broccoli: implications for cancer
Veeranki OL, Bhattacharya A, Marshall JR, Zhang Y.
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.

Cancer Prevention with Broccoli Sprouts.

2 the Cell Cycle broken down for us on Sun Sep 09, 2012 1:10 pm


Senior Member
Senior Member

Thanks so much for this great post. WOW

3 Re: Health Benefits of Broccolli on Wed May 22, 2013 3:42 am


All-Star Member
All-Star Member
there is another good reason to eat your greens. Broccoli, the
superfood already credited with the potential to fight cancer,
cataracts and stomach ulcers, has been found to aid diabetics.

Researchers believe a compound in the vegetable could reverse the negative effects of diabetes on the heart.

While studies are at an early stage, scientists believe broccoli could
be a significant weapon in the battle against heart disease.

Diabetes raises the likelihood of developing cardiovascular disease five-fold.

A team from the University of Warwick found that the compound
sulforaphane, found in broccoli, can encourage the body to produce
enzymes that protect the blood vessels.

It also reduces levels of the molecules which cause significant cell damage.

Previous research has shown that a diet rich in vegetables,
particularly brassica vegetables like broccoli, is linked to a reduced
risk of heart disease and stroke.

In the current study, published in the journal Diabetes, Professor Paul
Thornalley and colleagues tested the effects of sulforaphane in the lab
on blood vessel cells damaged by high glucose levels – hyperglycaemia.

They found that adding the compound reversed the increase in molecules
in the body called reactive oxygen species (ROS) by 73 per cent.
Hyperglycaemia – a serious problem among diabetes – can cause ROS
levels to increase threefold and such high levels can damage human

The researchers also found sulforaphane activated a protein in the body which protects cells and tissues from damage.

Prof Thornalley said: "Our study suggests compounds such as
sulforaphane may help counter processes linked to the development of
vascular disease in diabetes.

"It will be important to test if a diet rich in brassica vegetables has
health benefits for diabetic patients. We expect it will."

The finding could be welcome news for the almost 200,000 people in Scotland with diabetes.

Dr Iain Frame, director of research at Diabetes UK, pointed out that
the current research had focused on cells grown in a lab, some way from
real life.

"However," he said, "it is encouraging to see that Prof Thornalley and
his team have identified a potentially important substance that may
protect and repair blood vessels from the damaging effects of diabetes.

"It also may add some scientific weight to the argument that eating broccoli is good for you."

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